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Construction of multilayered molecular reservoirs on a titanium alloy implant for combinational drug delivery to promote osseointegration in osteoporotic conditions

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Parabiosis experiments further confirmed that these macrophages are recruited from the circulation rather than generated by local cardiac proliferation (69).Activated macrophages, together with infiltrating T lymphocytes, accumulate in the myocardium and release pro-inflammatory cytokines, thereby exacerbating myocardial injury and structural remodeling (70)

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