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Treatment of these cells with lapatinib, statins, trigonelline, or through genetic editing to suppress GPX4 expression can induce ferroptosis and reverse their tumor-promoting functions [28, 58, 88]

Prior to imaging, HepG2 cells were stained with 100 ng/mL Hoechst 33342 to visualize the nuclei

Fresh leaf sample grounded in extraction buffer comprising of Na-phosphate (0.5 M, pH 7.3), EDTA (3 mM), Triton X 100 (1% v/v) and PVP (1% w/v)

doi: 10.1016/j.bbrc.2018.11.021 196 RahmatiH.MomenabadiS.VafaeiA