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A solution was proposed by Elgogary et al
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Ren J, Bharti A, Raina D, Chen W, Ahmad R, Kufe D
Biased agonism at MOR and desensitization Functional studies revealed that [D-Ala 2 -MePhe 4 -Gly 5 -ol]enkephalin (DAMGO) induced a stronger desensitization of MOR than morphine in different experimental models and signaling pathways (Yu et al., 1997
