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Similarly, curcumin, a component of curcuma, induced the Nrf2-driven gene HO1, while analogs like carnosic acid (found in rosemary and sage), salvianolic acids (from sage), mangostin (from mangostan), and taxifolin (from conifers) all induced Nrf2 itself [261]

However, Skp2 has been identified as E3 ligase for FOXO1, whereas Mdm2 is the prime E3 ligase for p53

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2 Therefore, patients should be instructed to use eye lubricants such as artificial tears hourly and eye ointments at night because of the possibility of eye irritation from the facial paralysis