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Changes in the intestinal microbiota of patients with inflammatory bowel disease with clinical remission during an 8-week infliximab infusion cycle

Presenilins serve as the secretase's catalytic subunit in the production of the A peptide [82,83,84] Unrelated to -secretase activity, we recently learned that presenilins serve as low-conductance, passive endoplasmic reticulum (ER) calcium (Ca2 +) leak channels

Gore ME, Fryatt I, Wiltshaw E, Dawson T, Robinson BA, Calvert AH

This helps the liver to perform its normal functions
