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In addition to activating the Akt signaling pathway, this drug facilitates apoptotic cell death, which is linked to increased phosphorylation of MEK and its downstream target ERK, decreased Bcl-2 levels, increased Bax expression, and greater activation of caspase-3 and caspase-9
doi: 10.1080/03602532.2017.1415928 54 Di BonaM.ChenY.AgustinusA
Castilla-Cortzar I, Pascual M, Urdaneta E, Pardo J, Puche JE, Vivas B, Daz-Casares A, Garca M, Daz-Snchez M, Varela-Nieto I, Castilla A, Gonzlez-Barn S
