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When damaged mitochondria is unable to maintain their membrane potential, it needs to be degraded through mitophagy (Forbes and Thorburn, 2018
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For instance, SCB-313, a fully human TNF-related apoptosis-inducing ligand (TRAIL)trimer fusion protein, was created by fusing the human C-propeptide of 1 collagen, a trimer tag, in-frame to the C-terminus of human TRAIL, yielding a disulfide bond-linked homotrimer, as shown in Figure 6 [98]
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