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Increased proliferation of cortical progenitors is dependent on the apical (ventricular) localisation of the Igf-1r that is mediated through the cell polarity protein Pals-1 (Protein Associated with Lin Seven 1) as part of the apical complex

Many studies have shown that GSTP1 interacts with JNK and inhibits its activity, thereby suppressing the activation of downstream targets [56,57,58]
