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Our study suggested that colchicine is a potential drug candidate for the treatment of HBV and HBV-related HCC by targeting the HBc protein
110 A originates from the processing of the APP, a transmembrane glycoprotein, through its sequential cleavage by -secretase and -secretase (a multiprotein complex with PS1 or PS2 as catalytic subunits)
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The LAT subunits are members of the amino acid polyamine cation (APC) superfamily 32 , which exhibit a conserved 5 + 5 inverted topology fold, wherein the first five TM helices are related to the second five helices via a pseudo two-fold symmetry axis running parallel to the plane of the membrane 33
