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Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice

200400 mcg Once daily, SubQ 412 weeks TB-500 Regulates actin, the structural protein cells need to move

2022 Jul 6

Crossing these Jnk1 LoxP/LoxP / Jnk2 -/- mice with Alb-Cre mice produced Jnk hepa ( Jnk hepa mice developed higher liver injury than wild-type animals after APAP overdose, suggesting a beneficial role for combined Jnk1 and Jnk2 activation in hepatocytes during APAP-induced hepatotoxicity
