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While early anecdotal evidence suggested significant clinical symptomatic improvements, the five clinical trials identified in a recent meta-analysis used small populations with different clinical syndromes, measured different outcomes, and yielded no overall evidence of benefit [109]

doi: 10.1007/s00726-013-1493-1

One study conducted in 49 healthy women (with 149 cycles and 554 phases accounted), reported a significant increase in glucose levels during the luteal phase and a minimum in the late follicular phase, although the absolute differences in mean glucose were small despite being statistically robust [98]