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Manson, L

J Biol Chem 272:3078030786

Cardiometabolic Research Applications: The peptide has been evaluated in cardiac and metabolic research contexts

Receptor activation promotes regulatory T-cell (Treg) differentiation and activity, increases the production of anti-inflammatory cytokines such as interleukin-18 (IL-18), and helps maintain the Th17/Treg balance, thereby attenuating the pro-inflammatory responses characteristic of active IBD [17, 18]
