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DSIP has been evaluated in experimental frameworks examining stress-induced changes in neuroendocrine signaling

After incubation, cells were washed with PBS and left in warm serum-free media for imaging at a Zeiss LSM700 confocal microscope

About 95% of serotoninour feel-good neurotransmitteris produced in the gut

This dualistic outcome likely stems from the distinct physiological roles of lactate and associated acidosis: elevated lactate itself may not impair muscle function and might even support performance, yet the concomitant severe intracellular acidosis (pH 6.56.2), especially in fast-twitch fibers, reduces calcium sensitivity and impairs myosin ATPase activity, ultimately inducing muscle fatigue