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Since carbonyl content reflects the extent of protein oxidation, the elevated levels of protein carbonyls serve as an indicator of oxidative tissue damage [25, 26]

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Folic acid losses of 018% and 2443% after 3 and 9 months of storage under typical tropical conditions (40 C and 60% relative humidity), resp., were observed in rice extruded products prepared from rice flour fortified with folic acid and various iron compounds

Part of it is secondary to oxidative stress, which is well documented to occur during endotoxemia (Zhang et al., 2000)