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This article further reviews the latest progress in iron-targeting drug development, encompassing natural compounds (e.g., Diosgenin, Nuciferine, Xanthohumol), artificial extracts (e.g., sulfated polysaccharides), small molecule inhibitors (e.g., GLX351322), modifications of traditional drugs (e.g., Donafenib), and novel nanomaterials (e.g., GOA/miR-targeted nanocomposites, mitochondrial-targeted antioxidants like MitoTEMPO and MnO2Nfs), while also examining the potential limitations of these strategies

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Published Safety Observations Published rodent studies have not reported significant systemic toxicity, organ damage, or mortality at commonly used research doses

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