glp 1 drug mechanism of action Frontiers Consensus Recommendations on GLP-1 RA

Proper dosing schedules become essential because higher doses lead to more frequent side effects such as gastrointestinal upset, and the side effects can be managed by using the minimum effective dose or slow titration (Figure 2)

Serious but Rare Side Effects: Kidney damage

Of note, this approach to ICP monitoring was chosen by the patient advisory group due to the negative impact reported by repeated lumbar punctures [23, 24], and the use within the trial was carefully discussed with the individual participants during the consent process

Tirzepatide is also contraindicated in individuals with a history of multiple endocrine neoplasia syndrome Type-2 (MEN 2)