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Furthermore, this analysis found no clear advantages of nutritional interventions, noting that only a limited number of such trials were assessed [145]

Translational percentages (concordance rates) of results exhibit a wide range from 0100% with no predictable factors for translational success or failure in humans (309), and even multiple experiments fail to significantly contribute to improving the reproducibility of animal testing, accounting for 41%72% of the observed total variance (310, 311)

Taking the capsule between meals optimizes the conditions for successful delivery past the stomach

That said, it always pays to err on the side of caution and I wouldn't use out of date ones in somebody else, unless I had no option