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It was originally described as an endemic disorder in the Chuvash region of Russia, and has since been found as an endemic disorder in the island of Ischia and as a sporadic disorder in other locations and ethnic groups

doi: 10.1038/nature06902 26

Loss of weight exceeding 20% of normal body weight was the humane endpoint for this study

Effects of stereotactic neurosurgery on postural instability and gait in Parkinsons disease
