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Nitrate-class medications (Major interaction - do not combine without medical supervision): L-Citrulline and L-Arginine may increase blood flow and potentiate the hypotensive effects of nitrate medications, including nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat) and isosorbide (Imdur, Isordil)

Because of tyrosines role in the creation of thyroid hormones, it should not be taken at the same time as thyroid medication unless under direct advice from a qualified healthcare professional

Because there are serious adverse side effects associated with high-dose niacin, niacin therapy should only be conducted under the supervision of a qualified health care provider

Developmental Biology, 357 , 428438