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It plays a significant role in promoting moderate mitochondrial stress, which activates Nrf2, adenosine 5-monophosphate-activated protein kinase (AMPK), and SIRT1 and SIRT3, all of which are involved in anti-inflammatory and antioxidant responses (188)
Figure 1 illustrates the multifaceted effects of ashwagandha, demonstrating its systemic adaptogenic potential through four primary domains: immunomodulation, stress attenuation, neuroprotection, and cognitive enhancement
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