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doi: 10.1016/j.molcel.2006.06.026

Overall, the safety profile of GENVOYA in subjects in this study was similar to that of treatment-nave subjects [see Clinical Studies (14.3)]

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Additionally, busulfan can decrease Bcl-2 gene expression (as an antiapoptotic gene) and increase Bax gene expression (as a proapoptotic gene) in epididymal sperm of busulfan treated mice, which are related to increased oxidative stress as a result of decreased enzymatic antioxidants of GPx and SOD and increased level of lipid peroxidation in sperm cell (50)