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GHD is associated with increased visceral fat and dyslipidemia, while GH excess in acromegaly induces IR and glucose intolerance, adding cardiometabolic burden to the direct myocardial effects of GH/IGF-1 excess
doi: 10.1016/j.bcp.2015.02.003 214 LeeE

CSCs are a subpopulation of tumor cells with the capability to self-renew and differentiate, which drives tumor progression and metastasis