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Furthermore, its pro-angiogenic effect appears to be highly targeted

Therefore, it remains unclear if ER mutations are clinically relevant to antiestrogen resistance (Levenson et al ., 1997)

The relationship between the intron phase and sequence conservation at splice sites is associated with the evolution of spliceosomal introns ( PavGST classes, Subfamilies I, II, III, IV, and V exhibited peak conservation whereas subfamily VI, and VII showed a greater number of introns and mixed conservation at the splice site sequence (Figure 2)