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In 5 patients treated with LC, the levels of serum total carnitine, free carnitine, and acylcarnitine before and after administration increased significantly from 42.0 24.3 mol/L to 155.0 114.8 mol/L, 26.4 15.3 mol/L to 102.9 80.1 mol/L, and from 16.8 10.1 mol/L to 60.8 34.3 mol/L (Figure 3)

Similarly, the anthocyanin cyanidin-3-O-glucoside (C3G), abundant in many fruits and vegetables, induces early increases in thermogenic markers, including UCP1 and PGC-1, during preadipocyte differentiation [94]

Without any clear rationale, the study outcome measures were purposefully modified midtrial to alter the findings in favour of their hypothesis (549, 550)

Brain MRI often shows the characteristic Dawsons fingers, whereas spinal cord lesions usually extend to fewer than two vertebral segments