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Description
The decrease in the therapeutic effect of opioids can be explained by the commonality of the downregulation of opioid receptors in both the PNS and/or CNS under NP status and the long-term, repeated use of opioids (Figure 1)
Sci Rep 15 , 18857 (2025)
& Beck, E
Arterioscler Thromb Vasc Biol 2007
