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While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes along with dietary sources of carnitine from protein-rich red meat, for example dietary supplementation of carnitine may pose benefits in certain physiological conditions

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The sex difference in serine-312 phosphorylation of IRS-1 (pSer-IRS-1) may be akin of an increased vulnerability and a more advanced stage of brain IR in women than men with MDD