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Description
Mice were sacrificed at 7 dpl, as described below, for snRNA-seq and RNAscope/IHC for the demyelination timepoint, at 28 dpl for RNAscope/IHC at the remyelination timepoint, and at 42 dpl for the late recovery timepoint
Since antibiotics do not distinguish between beneficial or harmful organisms, antibiotics can diminish the beneficial gut flora responsible for thiamine production
These results are consistent with results observed in mice (26) and strongly support a role for gut microbiota in BB generation from dietary l-carnitine in humans
Curt Freed at the University of Colorado, USA
