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Our domain analysis using Uniprot, SMART, and conserved domain database (CDD) tools, revealed the presence of two conserved domains, the N-terminal domain (GSH binding site), and the C-terminal domain (substrate binding site) (Fig

Similarly, under oxidative stress, EGCG not only failed to provide protection in hydrogen peroxide-induced model but also worsened mitochondrial membrane potential loss, caspase-3 activation, and DNA fragmentation, suggesting potential pro-apoptotic and mitochondria-damaging effects under such conditions (Sahadevan et al., 2023)