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[Google Scholar] 93.Mackenzie S., McIntosh L

Clinical insights into dry eye disease Dry eye disease (DED) is a multifactorial disorder characterized by a deficiency in tear production or excessive tear evaporation resulting in ocular surface disruption, inflammation and discomfort

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A supplier reference for formulators notes that alpha arbutin is water soluble , should be processed at a maximum temperature of 40C , is reported stable only within a pH range of 3.56.6 , and has recommended use rates of 0.22% , according to Lotioncrafter's alpha arbutin ingredient guidance