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Day 1: sore arm and fatigue Day 2: Bad arm pain (like someone shot me with a shotgun through my arm and then was beating the wound with a bat), mild chills, mild nausea, and fatigue By end of Day 3: Felt fine except for mild arm soreness

Severe allergic reactions, persistent swelling, and significant changes in energy levels or mood should not be ignored

Beyond its cytoskeletal effects, TB-500 forms functional complexes with PINCH (particularly interesting new cysteine-histidine-rich protein) and integrin-linked kinase (ILK), activating the survival kinase Akt while inhibiting TNF--induced NF-B activation through blocking of RelA/p65 translocation