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The matrix support is functionalized with the chelate ligand Nitilotriacetic Acid (NTA) in complex with the nickel ions (Ni2+) in a very stable octahedral structure

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As a statement made by one of the leaders in vitamin B12 field more than 10 years ago, Carmels idea of cobalamin deficiency should not be diagnosed unless megaloblastic changes are found is still followed by many physicians and health authorities when accepting B12 deficiency diagnosis.1 But as time goes by, evidence and clinical cases []