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Mitochondrial ROS are increased under hypoxia, ischemia/reperfusion injury, chemical stress, drug treatment, and under many pathophysiological conditions (Srinivasan and Avadhani, 2012)

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Without adequate levels of these trace minerals, the entire metabolic assembly line grinds to a halt, exacerbating insulin resistance and cellular starvation

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doi: 10.1038/s41568-020-0273-y 283 CasconeTMcKenzieJAMbofungRMPuntSWangZXuCet al

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a ) Heatmap representation of average expression values of 48 SPN marker genes 23 in the different sorted striatal populations

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