old tobacco pipes Antique Help Determining the Value of
Description
Nicotine alone has vasoconstrictor effects on the gums, but it avoids most of the damage (combustion, tar, direct irritation)

Not long after they relocated, he was diagnosed with deep vein thrombosis in his right calf and later dealt with multiple blood clots in his lungs

Preventing Tobacco Use Among Young People: A Report of the Surgeon General

Oxidative stress also upregulates plasminogen activator inhibitor-1 (PAI-1) and alters the bioavailability of nitric oxide in endothelial cells, which consequently promotes thrombus formation [91]
