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According to the Centers for Disease Control and Prevention (CDC), some notable symptoms of nicotine withdrawal include: Having cravings or urges to smoke cigarettes Feeling grouchy, irritated, or upset Feeling restless Having difficulty concentrating Having trouble sleeping Feeling hungrier or gaining weight Feeling anxious, sad, or depressed You may think of smoking cigarettes just to get rid of these withdrawal symptoms, especially if you depend heavily on nicotine to overcome negative emotions or simply want to relax a little bit after hours of working, socializing, and so on

Nicotine can also acutely impair endothelial function, reducing nitric oxide availability and potentially contributing to oxidative stress and inflammation (9, 27, 28)

Keep unused and used patches out of the reach of children and pets

In multi-unit housing, secondhand smoke can seep into adjacent units, potentially leading to disputes or legal actions from neighbors exposed to smoke