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RS has been found to play a crucial role in glucose homeostasis, fat metabolism, cholesterol levels and mineral absorption

Among adolescents aged 1217 years with obesity, prescription use increased from 0.1 percent in 2020 to 0.5 percent in 2023, representing a relative rise of more than 300 percent, although total usage remains below 1 percent

In June 2026, the FDA updated the OTC weight loss drug alli (orlistat) label to include a warning about the rare risk of kidney stones and acute kidney injury

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