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GLP-RT's tri-agonist receptor activity also makes it relevant for research examining metabolic rate and energy expenditure pathways

Insulin resistance and chronic hyperglycemia cause a cascade of pathological events in the brain, including neuroinflammation, impaired neurotransmitter systems and energy metabolism, oxidative stress, and vascular pathologies that ultimately lead to neurodegeneration, loss of synaptic plasticity, brain aging, cognitive impairment, and dementia

The proportions of ASCVD, obesity, and diabetes mellitus were examined

These observational data suggest a potential role for GLP-1 receptor agonists in both the prevention and the treatment of various SUDs, warranting further evaluation