glp-1 drug use before pregnancy is linked to some risks. Increased Risk of NICU Stays for Babies Born Mothers Prescribed Medications in the 90 Days Use of GLP-1 drugs early
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doi: 10.1055/s-0028-1082326 54 PuglisiSRossiniAPoliRDugheraFPiaATerzoloMet al
RodriguezPZhangVGratzlSDoDGoodwin CartwrightBBakerCet al

The Phase 2 trial reported 50 to 60 percent GI adverse event rates at higher doses, and split dosing is one approach explored to reduce that

No, GLP-1 receptor agonists are not specifically contraindicated in Crohn's disease, but caution is advised in patients with active or severe gastrointestinal disease
