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This framework highlights inter-organ crosstalk and positions adipose tissue health as a key determinant of liver outcomes, with important implications for risk stratification and therapeutic targeting

GLP-1 receptor agonists, SGLT2 inhibitors and DPP-4 inhibitors GLP-1 receptor agonists, sodium glucose co-transporter-2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors reduce the risk of MACE compared to placebo

3.7 Cancer risk by individual GLP-1 RA compound When stratified by individual GLP-1 RAs, liraglutide and semaglutide were associated with reduced risk of gastrointestinal cancers (HR 0.77 and 0.79, respectively), while dulaglutide showed a neutral association (HR 0.91, 95% CI: 0.721.14)