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PC2 (gene: Pcsk2 ) cleaves proglucagon to glucagon, and PC1/3 (gene: Pcsk1 ) cleaves proglucagon to GLP-1 ( The ability of alpha-cells to switch to GLP-1 as their main endocrine output represents an enormous therapeutic opportunity to manage diabetes

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While both of these medications can be effective at controlling blood glucose levels, they can also have side effects, and taking them together may increase the risk of certain adverse and unwanted effects