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Description
In addition, Ex-4 provides neuroprotection against ischemia-induced damage in the hippocampus by downregulating hypoxia-inducible factor-1 and modulating apoptosis through the increased B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X-protein (Bax) ratio, which is mediated by the GLP-1 receptor [48]
An injectable supramolecular nanofiber hydrogel (PA-GLP-1) has demonstrated sustained GLP-1 release for over 40 days and achieved blood glucose reduction and weight control outcomes comparable to daily semaglutide in a rat model of T2DM induced by STZ and nicotinamide (NA) [209]
Under current circumstances, we are not aware of any major delivery issues
Gastroenterology 146 , 669680 (2014)
